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What is acral skin

Acral peeling skin syndrome is a skin disorder characterized by painless peeling of the top layer of skin. The term acral refers to the fact that the skin peeling in this condition is most apparent on the hands and feet. Occasionally, peeling also occurs on the arms and legs Acral peeling skin syndrome (APSS) is an inheritable skin condition that causes painless peeling of the top layer of skin, typically on the hands or feet. This condition is very rare, and a..

Acral peeling skin syndrome: MedlinePlus Genetic

acral adjective Referring to the extremities, especially the distal extremities. Segen's Medical Dictionary. © 2012 Farlex, Inc Acral melanoma, sometimes called acral lentiginous melanoma, is a rare type of skin melanoma that forms on the palms, soles of feet, or under finger or toe nails. Acral melanoma is the most common type of melanoma among people with darker skin Acral lesions occur days after mild infectious symptoms if any. Casas C.G. et al. reported that it is a late onset manifestation and that it appears to be associated with a less severe presentation Melanocytes contain your skin color (known as melanin or pigment). In this type of melanoma, the word acral refers to the occurrence of the melanoma on the palms or soles. The word lentiginous.. This type of skin peeling is often accompanied by itching. Conditions that may cause skin peeling include: Allergic reactions. Infections, including some types of staph and fungal infections. Immune system disorders. Cancer and cancer treatment. Genetic disease, including a rare skin disorder called acral peeling skin syndrome that causes.

Acral lentiginous melanoma is a very rare type of skin cancer, and it affects people with darker skin more than any other demographic. Other types of melanoma are caused by sun exposure that.. Argyria is a rare skin disorder that causes the skin to change color into a blue or grayish hue Acral lentiginous melanoma is a type of melanoma arising on the palms of the hands, soles of the feet, or the underside of fingers or toes. What are the clinical features of acral lentiginous melanoma? Acral lentiginous melanoma starts as a slowly enlarging flat patch of discoloured skin. The characteristics of acral lentiginous melanoma include

Acral peeling skin syndrome: Definition, symptoms, and

Acral Lentiginous Melanoma This third form of in situ cancer typically affects hairless skin. It may appear as a black or brown mark underneath the fingernails or toenails, on the sole of the foot,.. Acral lentiginous melanoma is a rare type of skin cancer. It begins when the melanocytes in the skin grow out of control and form tumors. Melanocytes are the cells responsible for making melanin, the pigment that determines the color of the skin Acral Peeling Skin Syndrome Symptoms of this rare disease include painless peeling of the top layer of your skin. The condition usually begins at birth or during early childhood Acral lentiginous melanoma is a type of melanoma arising on the palms or soles. It is a form of melanoma characterised by its site of origin: palm, sole, or beneath the nail (subungual melanoma). It is more common on feet than on hands. It can arise de novo in normal-appearing skin, or it can develop within an existing melanocytic naevus (mole) When melanoma occurs in people with darker skin, it's more likely to occur in a hidden area. Hidden melanomas include: Melanoma under a nail. Acral-lentiginous melanoma is a rare form of melanoma that can occur under a fingernail or toenail. It can also be found on the palms of the hands or the soles of the feet

Figure 3-7 Histology of normal acral skin illustrating the thick and compact stratum corneum and the presence of a stratum lucidum (gray blue) in the lower portion of the horny layer. Figure 3-8 Ultrastructure of stratum corneum showing transition of intracellular tonofilaments within viable cells to anucleate stratum corneum at the epidermal. ALM is a type of melanoma that develops on the palms, soles, and the skin under the nails. ALM sometimes develops from an existing mole, but it can also occur for no apparent reason on healthy.. A lick granuloma, also known as acral lick dermatitis, is a skin disorder found most commonly in dogs, but also in cats. In dogs, it results typically from the dog's urge to lick the lower portion of one of their legs. The lesion can initially be red, swollen, irritated, and bleeding, similar to a hot spot (wet eczema) Acral lentiginous melanoma (ALM) is one of the most common types of melanoma for people with darker skin and it's important that we check everywhere for it. When your doctor or dermatologist says.. Melanoma is a group of serious skin cancers that arise from pigment cells (melanocytes); acral lentiginous melanoma is a kind of lentiginous skin melanoma. Acral lentiginous melanoma is the most common subtype in people with darker skins and is rare in people with lighter skin types

An Acral Nevus (AN) is a benign condition that occurs as a pigmented skin lesion on the palms or soles. The lesion is usually a poorly-defined flat mole, less than 1 cm in size. A majority of them arise during childhood and young adulthood. Acral Nevus is observed to occur spontaneously, and the cause is largely unknown As you'd expect linguistically, it's accompanied by visible spots on the skin. Unlike your regular freckled nose or the signature polka dots of a dalmatian or leopard, acral lentiginous melanoma (ALM) is not ordinary not desired. In fact, they're deadly. What is acral lentiginous melanoma Skin of Color Stats. Black patients with melanoma have an estimated five-year melanoma survival rate of 67 percent, versus 92 percent for whites. 1. Skin cancer represents 1 to 2 percent of all cancers in Blacks. 2. Skin cancer represents approximately 2 to 4 percent of all cancers in Asians. 2. Skin cancer represents 4 to 5 percent of all. Abstract Acral peeling skin syndrome (APSS) is an autosomal recessive skin disorder characterized by acral blistering and peeling of the outermost layers of the epidermis. [ncbi.nlm.nih.gov] Electronic address: Acral peeling skin syndrome (APSS) is an autosomal recessive skin disorder characterized by acral blistering and peeling of the. Peeling skin syndrome due to variants in the CHST8 and CSTA genes were reported in consanguineous Pakistani and in Bedouin families, respectively. In Japanese individuals, a particularly common deletion involving CDSN has been reported. In Europeans, acral PSS due to TMG5 variants is more common

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Acral definition of acral by Medical dictionar

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Superficial acral fibromyxoma (SAF) presents as a slow-growing solitary tumor that typically arises on the hands and feet, with a predilection for the periungual region of fingers and toes. The tumors are frequently asymptomatic, but may be uncomfortable with pressure or, on occasion, painful. The duration prior to resection has ranged from 3. Peeling skin, or desquamation, is a common condition in which the outer layer of skin (epidermis) is shed. It is associated with healing from damage to the skin from either internal or external causes, such as burns or exposure to environmental irritants such as the sun or wind. Peeling skin may also accompany internal disorders or diseases. Darkened skin can develop in people of all races. Melasma is increased skin pigmentation that usually occurs on sun-exposed surfaces of darkly complected individuals. Commonly, darkened skin appears as fairly small spots, called age spots or lentigines, which can be caused by sun damage acquired over a long period of time Skin involvement limited to hands, face, feet, and forearms (acral distribution) Dilated nailfold capillary loops, usually without capillary drop-out A significant (10 to 15 percent) late incidence of pulmonary hypertension, with or without skin calcification, gastrointestinal disease, telangiectasias (CREST syndrome), or interstitial lung diseas Acral peeling skin syndrome (APSS) is a condition with autosomal dominant inheritance, caused by changes in gene TG5, responsible for the production of transglutaminase 5 (TG5). 1 It presents at birth or in early childhood with the formation of blisters and subsequent peeling on the palms and soles. As the disease has a low incidence and little or no clinical repercussion, it tends to be.

A lick granuloma, also known as acral lick dermatitis, is a skin disorder found most commonly in dogs, but also in cats.In dogs, it results typically from the dog's urge to lick the lower portion of one of their legs. The lesion can initially be red, swollen, irritated, and bleeding, similar to a hot spot (wet eczema). The animal's incessant licking of the lesion eventually results in a. Microscopic (histologic) description. Histologic overlap exists with melanoma. May be junctional, compound or dermal. Lentiginous pattern more common than in nevi of non-acral sites. Often (61%) low level pagetoid, single cell migration into stratum spinosum ( Am J Surg Pathol 1995;19:792 ), summarized by MANIAC (Melanocytic Acral Nevus. Medical definition of acral: of or belonging to the extremities of peripheral body parts

Systemic disease (vasculitis, amyloidosis skin biopsy easier than bronchus) 2. Types of biopsy: a. Shave (epidermis and some dermis) b. Punch (gets all layers but small area) c. Ellipse (cuts off the whole lesion) d. Major excision (goes all the way to muscle) Diseases: 1. Dermatitis: a. Need to know location, superficial vs. deep, and. Acral peeling skin syndrome. At least 22 mutations in the TGM5 gene have been found to cause acral peeling skin syndrome. This condition is characterized by painless peeling of the top layer of skin that is most apparent on the hands and feet but can also affect the arms and legs

Acral-lentiginous melanoma is most common among people with darker skin. This type of melanoma represents up to 70 percent of melanomas in African Americans and 46 percent of all cases in Asians, according to the NCI. Acral-lentiginous melanoma may be found on the palms of the hands, soles of the feet and under the nails Background: Acral lentiginous melanoma has increased mortality compared with other melanoma subtypes and disproportionately affects ethnic minorities. Acral melanocytic lesions have not been well studied in diverse populations of the United States. Objective: We sought to assess the prevalence, awareness, and dermoscopic patterns of acral melanocytic lesions in skin-of-color and non-Hispanic. The irony in acral vitiligo is that the difficult areas are also the most visible areas and thus they become the most important areas to be treated. Vitiligo after all is a benign cosmetic disease with malignant psychological issues and it's the acral areas that are the ones which produce most stress and psychological issues in vitiligo patient Acral melanocytic lesions in the United States: Prevalence, awareness, and dermoscopic patterns in skin-of-color and non-Hispanic white patients. J Am Acad Dermatol . 2016;74(4):724-30. Merkel EA and Gerami P. Malignant melanoma of sun-protected sites: a review of clinical, histological, and molecular features

Acral lentiginous melanoma is a form of melanoma characterized by its site of origin: palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma is more common on feet than on hands. It can arise de novo in normal-appearing skin, or it can develop within an existing melanocytic nevus (mole) At times peeling skin syndrome is confined to the hands and feet only; and in such a case it is called the Acral Peeling Skin Syndrome. Advertisement . What are the Causes of Peeling Skin Syndrome? The main cause of peeling skin syndrome is a defective gene. It is when the child inherits the defective copy of the gene from both the parents that. Acral lentiginous melanoma: This dangerous subtype of skin cancer isn't thought to be caused by sun exposure; it's genetic and forms on the palms, the soles of the feet, or under a nail. It's the. acral-lentiginous melanoma an uncommon type of melanoma, although it is the most common type seen in nonwhite individuals, occurring chiefly on the palms and soles, and sometimes involving mucosal surfaces, such as the vulva or vagina. The characteristic lesion is an irregular, enlarging black macule, which has a prolonged noninvasive stage

Acral lentiginous melanoma (ALM) is one of the most common types of melanoma for people with darker skin and it's important that we check everywhere for it. When your doctor or dermatologist says. None of the children had any prior acral scaling or desquamation; only one patient had history of atopic dermatitis. In patients with systemic symptoms, skin manifestations occurred 3 to 21 days after systemic symptoms. The skin lesions involved the fingers only in four cases, the toes only in one case, and both fingers and toes in one case Acral nevi demonstrated a mutational spectrum very similar to that of nevi on sun-exposed skin, suggesting that acral nevi are unlikely to be the precursor lesion for the majority of acral.

Acral Melanoma - Melanoma Research Allianc

  1. Acral lentiginous melanoma is usually found on the palms of the hands and soles of the feet or around the big toenail. It can also grow under the nails. It is much more common on the feet than on the hands. This type is rare. 5 to 10 out of every 100 people diagnosed with melanoma (5 - 10%) have this type
  2. antly involving the feet and, to a lesser extent, hands [40, 51]. Rare cases of chilblain-like lesions involving other acral sites, such as the auricular region, were also reported
  3. In 1981, at the age of thirty-six, the popular Jamaican reggae musician died from a rare form of skin cancer called acral lentiginous melanoma (ALM). Diagnosed several years earlier, Marley was advised to have his toe amputated, but refused, citing religious reasons and the potential impact it could have on his ability to perform
  4. Acral Melanoma. Acral melanoma is a rare type of skin melanoma that forms on the palms, soles of feet, and under finger or toe nails. Acral melanoma is the most common type of melanoma among people with darker skin. It is not believed to be caused by exposure to ultraviolet radiation
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[Dermoscopy in special locations : Nails, acral skin, face, and mucosa]. This may be explained by (1) a different anatomy of the skin and its adnexa in special locations in comparison to the remaining integument, (2) difficult technical access to special locations with a dermatoscope, and (3) a rather low incidence of malignant skin. Acral lick granulomas (also known as acral lick dermatitis), typically seen on the front part of the lower leg in dogs, are lesions that develop as a result of chronic and compulsive licking. The term comes from the location (acral, or belonging to the extremities) and the cause (licking) Acral lentiginous melanoma is a type of melanoma arising on the palms or soles of the feet. Acral lentiginous melanoma is not just a fancy name for melanoma on the fingers, toes, palm, soles of the feet, and under the nails, but it is also a type of melanoma that is the rarest among melanomas, accounting for only 2% to 3% of melanoma cases

Melanoma is a dangerous skin cancer that is generally known for attacking fairer skinned individuals. Not all melanomas have a strong connection with UV exposure, and these may not even be highest in proportion in Caucasian populations. Dark skinned vulnerability Acral lentiginous melanoma is one such disease that i A college student developed a rare cancer on her thumb after biting her nails. Find out more about acral lentiginous melanoma symptoms and prognosis

Acral lick dermatitis is the skin lesion that occurs when dogs repeatedly lick at specific sites on one or more of their limbs, often causing significant damage. Large breeds such as Doberman pinschers, Great Danes, German shepherds, Labrador retrievers, golden retrievers, and Irish setters are most commonly affected Lick granuloma which is also known as canine acral lick dermatitis (ACL) is a skin injury resulting from excessive licking. When a dog persistently licks its skin, it results in inflammation. With time, the skin thickens and due to the continuous licking, the area cannot heal. It results in a lick-inflammation vicious cycle But acral skin cancer is different because the gene faults that drive it aren't caused by UV damage. Pinpointing these faults is a major step towards understanding what causes this unique form of.

Acral lentiginous melanoma (ALM) is a specific type of melanoma that appears on the palms of the hands, the soles of the feet, or under the nails. Melanocytes contain your skin color (known as melanin or pigment). In this type of melanoma, the word acral refers to the occurrence of the melanoma on the palms or soles Acral lentiginous melanoma is most common in people with dark skin, such as those from African, Asian and Hispanic ancestries. It is not related to being exposed to the sun. It makes up less than 5% of all melanoma skin cancers. Acral lentiginous melanoma appears as a small, flat spot of discoloured skin that is often dark brown or black Melanoma is one of the most common types of cancer, with an estimated 100,000 new cases diagnosed in 2020 in the United States. Acral melanoma is a subtype on nonsun-exposed areas of the skin and. Because acral lentiginous melanoma tends to grow in more unusual areas, such as palms, soles, and under nails, surgery may be a bit more complex. This is especially true since acral lentiginous melanoma usually isn't diagnosed till it's already pretty advanced and may have grown more deeply into the skin

Lick granuloma is a common skin problem in dogs that is very frustrating for the dog, the owner, and the veterinarian. It is caused by the dog licking herself in the same area over and over. This causes trauma to that area of the skin and leads to a large wound, infection, and thickening of the skin

Acral Lesions: What We Know - How I Treat COVID-1

LearnDerm: Acral. Acral. Acral distribution of skin lesions involves the distal aspects of the head (ears, nose) and the extremities (hands, fingers, feet, toes). Chilblains (Perniosis Normal acral anatomy: In order to understand the dermoscopic features of pigmented lesions on acral skin it is essential to appreciate the unique anatomy of the skin in those areas. The undulating surface gives rise to fingerprints (dermatoglyphs) with the alternating ridges and furrows. In benign naevi, melanocytes tend to transfer melanin to. At an acral skin temperature of about 21°C, finger blood flow is constantly low. At lower temperatures the fingers and toes become painful. This is a normal physiologic reaction, probably because of ischemia. The characteristics of the most frequent acral vascular syndromes, Raynaud phenomenon, acrocyanosis, and chilblains, are discussed.

Acral Lentiginous Melanoma: Symptoms, Prognosis, and Mor

In particular, SAVI associates both acral skin and lung damage, and auto-antibodies. They have recently been identified as type I interferonopathies. Hallmark is interferon signature, i.e. hyperexpression of type I interferon in the blood. The investigators hypothesize Covid-19 may lead to similar skin involvement as in type I interferonopathies Acral melanoma is distinct from melanoma of other cutaneous sites, yet there is considerable variation within this category. To better define this variation, we assessed melanomas occurring on dorsal (n = 21), volar (n = 9), and subungual/interdigital (n = 13) acral skin as well as acral nevi (n = 24) for clinical, histologic, and molecular features

Peeling skin Causes - Mayo Clini

Acral volar skin is the most prevalent site of malignant melanoma in nonwhite populations. In 2007, our group proposed a 3-step algorithm for the management of acquired melanocytic lesions affecting acral volar skin (). 1 We now know that almost all acral melanomas arise de novo, not in association with a preexisting acral nevus. 2 Given that an acral nevus has virtually no risk of developing. More than half of dogs with acral lick dermatitis are suspected to have concurrent fear- or anxiety-based conditions or both (e.g. separation anxiety, noise phobia, anxiety-related aggression). The condition incites the affected patient to excessively lick an area or areas, causing hair loss and erosion of the superficial skin layers Acral skin is the most prevalent site of malignant melanoma in non‐Caucasian populations. On acral skin, other various kinds of pigmented lesions are also detected. Particularly, melanocytic nevus is commonly seen on acral volar skin; approximately 10% of Japanese have a nevus on their soles

Acral Lentiginous Melanoma: How Does it Impact Your Health

Acral lentiginous melanoma is the most common type of melanoma in black Americans. 6 It makes up about 36% of melanomas among blacks, 18% in Asian/Pacific Islanders, 9% in Hispanic whites, and only 1% in non-Hispanic whites. 7 The average age at diagnosis is 63 years. The number of skin changes suspected to be associated with COVID-19 keeps growing. Classic cold-induced chilblains is a benign and self-limited condition characterized by acral erythema of the. Acral lentiginous melanoma or ALM is a type of skin cancer. It is often misjudged and goes unnoticed until the cancer cells have progressed. ALM develops on the hands (palms) and soles of your feet. About 1-3% of the people detected with melanoma develop ALM. This type of skin cancer targets white complexioned people and [ Sir, Acral peeling skin syndrome (OMIM #609796), first described in 1921 by Fox, is an autosomal recessive cutaneous disorder caused by mutations in the transglutaminase-5 (TGM5) gene and, less frequently, in the cystatin A (CSTA) gene. Acral peeling skin syndrome is a rare disease with unknown prevalence and with dozens of cases described in the medical literature so far The condition is a skin disorder that forms when a cat or dog excessively or compulsively licks a specific area of the body. Sometimes the ailment is called acral lick dermatitis, acral lick granuloma, or acral lick furunculosis. It often starts with a small scratch or injury to the body

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  1. Acral melanoma is a subtype on nonsun-exposed areas of the skin and is not linked to ultraviolet radiation exposure. Despite both conditions being derived from pigment-producing melanocytes, melanoma and acral melanoma differ in several ways
  2. Acral - Related to the extremities and the more distal parts of the body Actinic - Relating to biochemical changes in the skin produced by sunlight energy from both the visible and ultraviolet.
  3. Acral lentiginous melanoma rarely affects light skinned people. However, it is one of the most common subtypes of melanoma in Asians and people with dark skin. In fact, it accounts for up to 72% of melanoma cases in dark-skinned patients and less than 1% of Caucasian patients
  4. Acral lentiginous melanoma (ALM) is a type of melanoma that occurs on the palms of the hands or the soles of the feet. The condition can develop in normal-appearing skin or within an existing mole. ALM begins as a flat patch of discolored skin that may enlarge slowly over time. Although the cancer cells often remain contained at the skins.
  5. Named after their location - the hairless acral skin on the palms of the hands, soles of the feet and under the nails - these tumours are very different from the majority of melanomas that arise elsewhere on the hairy bits of the skin, which are known as 'cutaneous' melanomas
  6. During the coronavirus disease 2019 (COVID-19) pandemic, there has been a rise in the diagnosis of acral lesions, including chilblainslike lesions, ischemia, and retiform purpura. Understanding the differences in presentation and severity of illness between children and adult patients is important for physicians to understand risk stratification and management of these lesions
  7. ation is important in the detection of skin cancer. See Answe
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Acral lentiginous melanoma dermoscopy DermNet N

It was the day after Thanksgiving when I got a call from the dermatologist with the results. Your biopsy results came back and you have Acral Lentiginous Melanoma, she told me Microscopically, the section revealed a small fragment of acral skin. The epidermis was unremarkable. Within the dermal papillae there were regularly distributed Meissner's (tactile) corpuscles. In the papillary/reticular dermis was a poorly defined proliferation of haphazardly arranged,. The tumor typically arises on sun-damaged skin on the face, ears, arms or upper torso. What it looks like: It may look like a flat or slightly raised, blotchy patch with uneven borders. Color is usually blue-black, but can vary from tan to brown or dark brown. Acral lentiginous melanom

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Acral lesions: resemble dysplastic nevus due to elongation of rete ridges, continuous proliferation of melanocytes at dermoepidermal junction, single scattered melanocytes or less commonly small clusters within the upper epidermis; poor or absent lateral circumscription, melanocytes with abundant pale cytoplasm and round / oval, sometimes. Acral melanosis, ephilis (freckle) melanocytic macule are all characterized by increased melanin retention within the basal keratinocytes with _____ only a subtle increase in intra Epidermal melanocyte Acral Peeling Skin Syndrome (APSS) is considered to be a localized variant [4]. We present a case report of two siblings with APSS. Case presentation. Two siblings presented with asymptomatic peeling of the hands and the feet. The elder sibling was a 13 year old boy who developed peeling of the skin in the first year after birth. It was noticed. Find details on Skin: acral mutilation syndrome in dogs including diagnosis and symptoms, pathogenesis, prevention, treatment, prognosis and more. All information is peer reviewed Acral lick granuloma, also known as acral lick dermatitis, is a skin condition that typically affects the lower part of a dog's legs and feet.While brought on by chronic licking, there is typically an underlying factor that prompts the dog to focus on licking the area to excess

Acral Lentiginous Melanoma Memorial Sloan Kettering

Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients. Teramoto Y, Keim U, Gesierich A, Schuler G, Fiedler E, Tüting T, Ulrich C, Wollina U, Hassel JC, Gutzmer R, Goerdt S, Zouboulis C, Leiter U, Eigentler TK, Garbe C Br J Dermatol 2018. Acral erythema, or hand-foot syndrome, is a painful cancer rash that affects the palms of the hands and the soles of the feet. Patients often experience altered sensation in these areas prior to the actual rash formation. The skin may or may not blister, but frequently, the pain becomes so severe that patients have difficulty with everyday tasks Hypopigmentation is seen in a wide range of skin conditions. The morphology and distribution of hypopigmented lesions help in narrowing down the differential diagnosis. Several diseases present with guttate, speckled, or confetti hypopigmented macules, and cases of speckled hypopigmentation limited to acral areas have recently been described.1-4 In this report, we describe a 9-year-old girl. Background Checkpoint inhibitors (CPIs) are thought to be effective against cutaneous melanoma in part because of the large burden of somatic mutations (neoantigens) generated from exposure to ultraviolet radiation. However, rare melanoma subtypes arising from acral skin, mucosal surfaces, and the uveal tract are largely sun-shielded. Genomic studies show these sun-shielded melanomas have a.

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Scientists learn more about rare skin cancer that killed Bob Marley. Although acral lentiginous melanoma is rare in Caucasians and people with lighter skin types, it is the most common subtype in people with darker skins. Acral lentiginous melanoma is observed on the palms, soles, under the nails and in the oral mucosa Visual Diagnosis: Three Infants Who Have Perioral and Acral Skin Lesions Douglas Leonard , Rafet Koca , Ceyda Acun , Saniye Çinar , Emel Eştürk , Gonca Üstündağ , Sarah Herron , Mark M. Butterfly and Joseph A. Zene Although the cause of acral lentiginous melanoma is unknown, it does not appear to stem from sun exposure, explains Mitchell. Hale theorizes that ALM is more common in darker skin because the palms of your hands and soles of your feet tend to have less melanin. But this assumption doesn't completely line up, because the bottoms of your.

AMs can occasionally be unpigmented (amelanotic melanoma) and manifest as an eroded nodule of the acral skin or of the nail bed with nail plate abnormalities, revealing polymorphous vessels and milky-red or pinkish areas at dermoscopy. 5 Atypical presentations are not uncommon Peeling skin syndromes (PSSs) are a heterogeneous group of rare, autosomal recessive disorders characterized by superficial, painless peeling and blistering of the skin without mucosal fragility [ 1-3 ]. The two major forms are acral peeling skin syndrome (APSS; also called localized PSS) and generalized PSS [ 4-7 ] Acral lentiginous melanoma (ALM) is a form of lentiginous melanoma that typically originates on the feet, hands, toenails, fingernails, and inside mucous membranes. ALM accounts for only 5% of melanoma cases in the United States, but is the leading cause of skin cancer deaths. The disease initially appears as a bruise or nail streak on the skin Acral lentiginous melanoma is a form of cancer that attacks the palms, soles as well as under nail beds. This is a deadly type of cancer and is mostly found in Asians, African-Americans, and Hispanics. Acral melanoma mostly favors individuals of darker skin tones. Acral melanoma is not caused by sun exposure and is twice as likely to recur Postinflammatory acral pigmentation may follow both infectious and autoimmune diseases and may even be drug induced. A correct diagnosis is important to decide on the management which varies from reassurance and counseling to active treatment. This review paper is an attempt to classify acral pigmentation based on its diverse etiological causes